Structure-activity relationship of for-l-Met l-Leu-l-Phe-OMe analogues in human neutrophils

Neutrophils migrate to infected tissues along a concentration gradient of chemoattractant molecules, e.g. for-Met-Leu-Phe-OMe (fMLP-OMe). The aim of the studies reported herein was twofold: to clarify the mechanisms whereby the ligand hooks its specific receptor and to verify the biological consequences arising from every possible variations on the fMLP-OMe prototype.