کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1357812 981283 2015 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis, in vitro biological activities and in silico study of dihydropyrimidines derivatives
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis, in vitro biological activities and in silico study of dihydropyrimidines derivatives
چکیده انگلیسی

We describe here the synthesis of dihydropyrimidines derivatives 3a–p, and evaluation of their α-glucosidase enzyme inhibition activities. Compounds 3b (IC50 = 62.4 ± 1.5 μM), 3c (IC50 = 25.3 ± 1.26 μM), 3d (IC50 = 12.4 ± 0.15 μM), 3e (IC50 = 22.9 ± 0.25 μM), 3g (IC50 = 23.8 ± 0.17 μM), 3h (IC50 = 163.3 ± 5.1 μM), 3i (IC50 = 30.6 ± 0.6 μM), 3m (IC50 = 26.4 ± 0.34 μM), and 3o (IC50 = 136.1 ± 6.63 μM) were found to be potent α-glucosidase inhibitors in comparison to the standard drug acarbose (IC50 = 840 ± 1.73 μM). The compounds were also evaluated for their in vitro cytotoxic activity against PC-3, HeLa, and MCF-3 cancer cell lines, and 3T3 mouse fibroblast cell line. All compounds were found to be non cytotoxic, except compounds 3f and 3m (IC50 = 17.79 ± 0.66–20.44 ± 0.30 μM), which showed a weak cytotoxic activity against the HeLa, and 3T3 cell lines. In molecular docking simulation study, all the compounds were docked into the active site of the predicted homology model of α-glucosidase enzyme. From the docking result, it was observed that most of the synthesized compounds showed interaction through carbonyl oxygen atom and polar phenyl ring with active site residues of the enzyme.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 23, Issue 20, 15 October 2015, Pages 6740–6748
نویسندگان
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