کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1358097 | 981319 | 2014 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Synthesis of chlorophyll–amino acid conjugates as models for modification of proteins with chromo/fluorophores Synthesis of chlorophyll–amino acid conjugates as models for modification of proteins with chromo/fluorophores](/preview/png/1358097.png)
A chlorophyll-a derivative bonded directly with epoxide at the peripheral position of the chlorin π-system was reacted with N-urethane and C-ester protected amino acids bearing an alcoholic or phenolic hydroxy group as well as a carboxy group at the residue to give chlorophyll–amino acid conjugates. The carboxy residues of N,C-protected aspartic and glutamic acids were esterified with the epoxide in high yields. The synthetic conjugates in dichloromethane had absorption bands throughout the visible region including intense red-side Qy and blue-side Soret bands. By their excitation at the visible bands, strong and efficient fluorescence emission was observed up to the near-infrared region. The chromo/fluorophores are promising for preparation of functional peptides and modification of proteins.
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Journal: Bioorganic & Medicinal Chemistry - Volume 22, Issue 4, 15 February 2014, Pages 1421–1428