کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1358097 981319 2014 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis of chlorophyll–amino acid conjugates as models for modification of proteins with chromo/fluorophores
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis of chlorophyll–amino acid conjugates as models for modification of proteins with chromo/fluorophores
چکیده انگلیسی

A chlorophyll-a derivative bonded directly with epoxide at the peripheral position of the chlorin π-system was reacted with N-urethane and C-ester protected amino acids bearing an alcoholic or phenolic hydroxy group as well as a carboxy group at the residue to give chlorophyll–amino acid conjugates. The carboxy residues of N,C-protected aspartic and glutamic acids were esterified with the epoxide in high yields. The synthetic conjugates in dichloromethane had absorption bands throughout the visible region including intense red-side Qy and blue-side Soret bands. By their excitation at the visible bands, strong and efficient fluorescence emission was observed up to the near-infrared region. The chromo/fluorophores are promising for preparation of functional peptides and modification of proteins.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 22, Issue 4, 15 February 2014, Pages 1421–1428
نویسندگان
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