کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1358821 981369 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Discovery of new chromone containing sulfonamides as potent inhibitors of bovine cytosolic carbonic anhydrase
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Discovery of new chromone containing sulfonamides as potent inhibitors of bovine cytosolic carbonic anhydrase
چکیده انگلیسی

Series of chromone containing sulfonamides were prepared by the reaction of (un)substituted 3-formylchromones with 3-aminobenzenesulfonamide and 4-aminobenzenesulfonamide. Bovine carbonic anhydrase (bCA) inhibitory activity of these newly synthesized compounds was determined. All compounds were active and possessed excellent bCA inhibitory activities with IC50 values ranged between 4.31 ± 0.001 and 29.12 ± 0.008 μmol. Compounds derived from 6-fluoro-3-formylchromones were the most active.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 19, Issue 11, 1 June 2011, Pages 3367–3371
نویسندگان
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