کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1359301 | 981399 | 2013 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cytotoxic betulin-derived hydroxypropargylamines trigger apoptosis
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Cytotoxic betulin-derived hydroxypropargylamines trigger apoptosis Cytotoxic betulin-derived hydroxypropargylamines trigger apoptosis](/preview/png/1359301.png)
چکیده انگلیسی
Several novel betulin derivatives were prepared and evaluated for their antitumor activity. Among others, 3-O-acetylbetulinic aldehyde served as an ideal starting material for the synthesis of 28-acetylenic derivatives that were further transformed into Mannich bases. These hydroxypropargylamines were screened for their antitumor activity in a panel of nine human cancer cell lines in a sulforhodamine B (SRB) assay. Several compounds showed a noteworthy antitumor activity. The results from acridine orange/propidium iodide staining and annexinV-FITC assays as well as DNA laddering experiments provided evidence for an apoptotic cell death.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 21, Issue 2, 15 January 2013, Pages 425–435
Journal: Bioorganic & Medicinal Chemistry - Volume 21, Issue 2, 15 January 2013, Pages 425–435
نویسندگان
René Csuk, Ronny Sczepek, Bianka Siewert, Christoph Nitsche,