کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1360773 | 981447 | 2008 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Building skeletally diverse architectures on the Indoline Scaffold: The discovery of a chemical probe of focal adhesion kinase signaling networks
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Inspired by bioactive indoline alkaloid natural products, here, we report a divergent synthesis approach that led to skeletally diverse indoline alkaloid-inspired compounds. The natural product-inspired compounds obtained were then subjected to a series of in vitro and cellular assays to examine their properties as modulators of focal adhesion kinase (FAK) activity. This study resulted in the identification of a promising lead inhibitor of FAK (42), which also showed activity in a wound healing and cell invasion assay. The in silico study of the lead compound (42) was also undertaken.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 16, Issue 21, 1 November 2008, Pages 9596–9602
Journal: Bioorganic & Medicinal Chemistry - Volume 16, Issue 21, 1 November 2008, Pages 9596–9602
نویسندگان
Michael Prakesch, Krikor Bijian, Valérie Campagna-Slater, Sophie Quevillon, Reni Joseph, Chang-Qing Wei, Esther Sesmilo, Ayub Reayi, Rajamohan R. Poondra, Michael L. Barnes, Donald M. Leek, Bin Xu, Caroline Lougheed, Matthieu Schapira,