کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1361191 | 981458 | 2008 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Pyrimidinone-peptoid hybrid molecules with distinct effects on molecular chaperone function and cell proliferation
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Pyrimidinone-peptoid hybrid molecules with distinct effects on molecular chaperone function and cell proliferation Pyrimidinone-peptoid hybrid molecules with distinct effects on molecular chaperone function and cell proliferation](/preview/png/1361191.png)
چکیده انگلیسی
The Hsp70 molecular chaperones are ATPases that play critical roles in the pathogenesis of many human diseases, including breast cancer. Hsp70 ATP hydrolysis is relatively weak but is stimulated by J domain-containing proteins. We identified pyrimidinone-peptoid hybrid molecules that inhibit cell proliferation with greater potency than previously described Hsp70 modulators. In many cases, anti-proliferative activity correlated with inhibition of J domain stimulation of Hsp70.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 16, Issue 6, 15 March 2008, Pages 3291–3301
Journal: Bioorganic & Medicinal Chemistry - Volume 16, Issue 6, 15 March 2008, Pages 3291–3301
نویسندگان
Christine M. Wright, Raj J. Chovatiya, Nora E. Jameson, David M. Turner, Guangyu Zhu, Stefan Werner, Donna M. Huryn, James M. Pipas, Billy W. Day, Peter Wipf, Jeffrey L. Brodsky,