کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1361597 | 981467 | 2007 | 11 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Design, synthesis, and anticonvulsant activity of some sulfamides Design, synthesis, and anticonvulsant activity of some sulfamides](/preview/png/1361597.png)
As part of our search for potential anticonvulsant agents, a set of compounds were designed, synthesized, and evaluated against MES and PTZ tests. Bioisosteric functional group information was used to design a new functionality, sulfamides, that complies with the requirements of the pharmacophore previously defined. Some of the molecules showed a promising anticonvulsant profile as selective anti-MES drugs, being active at low concentrations (30 mg/kg). The biological data were confirmed in Phase II of the Anticonvulsant Drug Development Program of the National Institute of Health.
Anticonvulsant sulfamides were designed based on a proposed pharmacophore. They were synthesized and evaluated in preclinical phases. Some of the molecules show a promising anticonvulsant profile as selective anti-MES drugs.Figure optionsDownload as PowerPoint slide
Journal: Bioorganic & Medicinal Chemistry - Volume 15, Issue 16, 15 August 2007, Pages 5604–5614