کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1362035 | 981477 | 2007 | 13 صفحه PDF | دانلود رایگان |
Solid-phase synthesis of a small combinatorial library of dihydroceramide analogues as mixtures of erythro and threo diastereomers is described. Some dihydroceramide analogues cause growth arrest and apoptosis in a dose-dependent manner in human alveolar epithelial cells. This activity is likely due to the threo isomers, as evidenced by cellular studies with a pair of diastereomerically pure N-acyldihydrosphingosines. The apoptotic activity reported in this work provides information for the design of new compounds that may provide the basis for the generation of biochemical tools for the study of different pathologies where ceramide and/or dihydroceramide are involved.
A small combinatorial library of dihydroceramide analogues is described. Some of them cause growth arrest and apoptosis in a dose-dependent manner in human alveolar epithelial cells. These compounds may be useful as biochemical tools for the study of different pathologies where ceramide and/or dihydroceramide are involved.Figure optionsDownload as PowerPoint slide
Journal: Bioorganic & Medicinal Chemistry - Volume 15, Issue 1, 1 January 2007, Pages 50–62