کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1362825 | 981497 | 2007 | 9 صفحه PDF | دانلود رایگان |

Designed and synthesized were a series of pyridines substituted at 2, 4, and 6 positions with various 5- or 6-memberd heteroaromatics as antitumor agents. They were evaluated their topoisomerase I and II inhibitory activities along with cytotoxicities against several human cancer cell lines. Among the prepared compounds, 10–20 showed significant topoisomerase I or II inhibitory activities, and 21–26 showed considerable cytotoxicities against several human cancer cell lines. Structure–activity relationship study indicates that 4′-pyridine at 6-position of central pyridine plays a key role in biological activity.
Designed and synthesized were a series of pyridines substituted at 2, 4, and 6 positions with various 5- or 6-membered heteroaromatics as antitumor agents. They were evaluated for their topoisomerase I and II inhibitory activities along with cytotoxicities against several human cancer cell lines. Among the prepared compounds, 10–20 showed significant topoisomerase I or II inhibitory activity, and 21–26 showed considerable cytotoxicities against several human cancer cell lines. Structure–activity relationship study indicates that 4′-pyridine at 6-position of central pyridine plays a key role in biological activity.Figure optionsDownload as PowerPoint slide
Journal: Bioorganic & Medicinal Chemistry - Volume 15, Issue 13, 1 July 2007, Pages 4351–4359