کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1362828 981497 2007 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
C-Terminally PEGylated hGH-derivatives
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
C-Terminally PEGylated hGH-derivatives
چکیده انگلیسی

A two-step strategy was used for the preparation of C-terminally PEGylated hGH-derivatives. In a first step a CPY-catalyzed transpeptidation was performed on hGH-Leu-Ala, introducing reaction handles, which were used in the second step for the ligation of PEG-moieties. Both oxime-ligation and copper(I) catalyzed [2+3]-cycloaddition reactions were used for the attachment of PEG-moieties. The biological data show a dependency of the potency of the hGH-derivatives on both size as well as shape of the PEG-group.

Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 15, Issue 13, 1 July 2007, Pages 4382–4395
نویسندگان
, , , , , , , ,