کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1363623 981518 2007 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Benzoic acid and pyridine derivatives as inhibitors of Trypanosoma cruzi trans-sialidase
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Benzoic acid and pyridine derivatives as inhibitors of Trypanosoma cruzi trans-sialidase
چکیده انگلیسی

Benzoic acid and pyridine derivatives inhibit recombinant trans-sialidase from Trypanosoma cruzi with I50 values between 0.4 and 1 mM. The best compounds, 4-acetylamino-3-hydroxymethylbenzoic acid and 5-acetylamino-6-aminopyridine-2-carboxylic acid, provide new leads to inhibitors not containing the synthetically complex sialic acid structure. The weak inhibition by such compounds contrasts with their much stronger inhibition of neuraminidase from Influenza virus.

Benzoic acid and pyridine-carboxylic acid derivatives inhibit trans-sialidase from Trypanosoma cruzi with I50 values between 0.4 and 1 mM. The strongest inhibitors in this structural family were:Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 15, Issue 5, 1 March 2007, Pages 2106–2119
نویسندگان
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