An efficient synthesis and biological activity of substituted p-benzoquinones

An efficient synthesis of 2,5-diarylamino-3,6-dichloro-1,4-benzoquinone derivatives has been achieved by condensing mono substituted anilines with tetrachloro-p-benzoquinone in presence of fused sodium acetate as condensing agent under microwave irradiation without any solvent. All the synthesized compounds were tested for their antibacterial and antitumour activity using standard drugs.

Comparative profile of synthesis of substituted-p-benzoquinones is described. The synthesized compounds were screened for antibacterial and ‘in vitro’ antitumour activity.Figure optionsDownload as PowerPoint slide