کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1364246 | 981532 | 2007 | 9 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Regulatory molecules for the 5-HT3 receptor ion channel gating system Regulatory molecules for the 5-HT3 receptor ion channel gating system](/preview/png/1364246.png)
Substituted benzoxazole derivatives which possess a nitrogen-containing heterocycle at C2 are selective partial agonists of the 5-HT3 receptor. Alteration of substituents on the benzoxazole nucleus affords both agonist-like and antagonist-like compounds, and uniquely modifies the function of the 5-HT3 receptor ion channel gating system. SAR and corroborative computational docking study for these partial agonists successfully explained structure and function of the 5-HT3 receptor.
Substituted benzoxazoles uniquely modify the function of the 5-HT3 receptor ion channel gating system. SAR and computational study explained structure and function of the 5-HT3 receptor (EWG:electron withdrawing group, EDG: electron donating group).Figure optionsDownload as PowerPoint slide
Journal: Bioorganic & Medicinal Chemistry - Volume 15, Issue 10, 15 May 2007, Pages 3515–3523