Regulatory molecules for the 5-HT3 receptor ion channel gating system

Substituted benzoxazole derivatives which possess a nitrogen-containing heterocycle at C2 are selective partial agonists of the 5-HT3 receptor. Alteration of substituents on the benzoxazole nucleus affords both agonist-like and antagonist-like compounds, and uniquely modifies the function of the 5-HT3 receptor ion channel gating system. SAR and corroborative computational docking study for these partial agonists successfully explained structure and function of the 5-HT3 receptor.

Substituted benzoxazoles uniquely modify the function of the 5-HT3 receptor ion channel gating system. SAR and computational study explained structure and function of the 5-HT3 receptor (EWG:electron withdrawing group, EDG: electron donating group).Figure optionsDownload as PowerPoint slide