Fluorination of triptolide and its analogues and their cytotoxicity

The reaction of triptolide and its analogues with a fluorinating agent, that is, bis(2-methoxyethyl)aminosulfur trifluoride (Deoxo-Fluor) or (diethylamino)sulfur trifluoride (DAST), was studied. One of the fluorinated products, 14β-dehydroxy-14β-fluoro triptolide, was found to be more cytotoxic than the parent natural triptolide.

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