کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1365491 | 981562 | 2006 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis of pyrazole-based hybrid molecules: Search for potent multidrug resistance modulators
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Synthesis of pyrazole-based hybrid molecules: Search for potent multidrug resistance modulators Synthesis of pyrazole-based hybrid molecules: Search for potent multidrug resistance modulators](/preview/png/1365491.png)
چکیده انگلیسی
The hybrid molecules have been designed on the basis of the structural features of pyrazole-based drugs and MDR modulator propafenone. A simple synthetic strategy and solvent-based regioselectivity have been used for the synthesis of newly designed molecules and they are evaluated for their interactions with P-glycoprotein (P-gp). Some of the molecules show considerable interactions with P-gp and compounds 15, 28 and 40 could be the potential candidates for their use as MDR modulators.
The hybrid molecules C and D obtained by combining the structural features of pyrazole-based drugs (A) and propafenone (a modulator) (B) have been synthesized and evaluated for their interactions with P-glycoprotein.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 14, Issue 14, 15 July 2006, Pages 5061–5071
Journal: Bioorganic & Medicinal Chemistry - Volume 14, Issue 14, 15 July 2006, Pages 5061–5071
نویسندگان
Palwinder Singh, Kamaldeep Paul, Wolfgang Holzer,