Improved radiosynthesis of the apoptosis marker 18F-ICMT11 including biological evaluation

We improved the specific radioactivity of the apoptosis imaging isatin derivative 18F-ICMT11. We then evaluated 18F-ICMT11 in EL4 tumor-bearing mice 24 h after treatment with etoposide/cyclophosphamide combination therapy. Dynamic PET imaging demonstrated increased uptake in the drug-treated (0.115 ± 0.011 SUV) compared to the vehicle-treated EL4 tumors (0.083 ± 0.008 SUV). This effect correlated to the observed increases in apoptotic index.

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