کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1374183 981914 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Design of potent thiophene inhibitors of polo-like kinase 1 with improved solubility and reduced protein binding
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Design of potent thiophene inhibitors of polo-like kinase 1 with improved solubility and reduced protein binding
چکیده انگلیسی

A series of thiophene PLK1 inhibitors was optimized for increased solubility and reduced protein binding through the appendage of basic amine functionality. Interesting selectivity between PLK1 and PLK3 was also obtained through these modifications.

Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 19, Issue 6, 15 March 2009, Pages 1694–1697
نویسندگان
, , , , , , , , , , , ,