کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1375517 1500650 2014 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Porous starch/cellulose nanofibers composite prepared by salt leaching technique for tissue engineering
ترجمه فارسی عنوان
کامپوزیت نانو فیبر نشاسته / سلولز متخلخل تولید شده توسط روش لیشاندن نمک برای مهندسی بافت
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
چکیده انگلیسی


• The cellulose nanofibers were extracted from rice straw.
• Starch/cellulose nanofibers composites were fabricated via film casting as scaffold.
• Salt leaching and freeze drying methods were applied out to increase porosity.
• Adhesion and proliferation of chondrocyte cells were investigated on the scaffolds.

Starch/cellulose nanofibers composites with proper porosity pore size, mechanical strength, and biodegradability for cartilage tissue engineering have been reported in this study. The porous thermoplastic starch-based composites were prepared by combining film casting, salt leaching, and freeze drying methods. The diameter of 70% nanofibers was in the range of 40–90 nm. All samples had interconnected porous morphology; however an increase in pore interconnectivity was observed when the sodium chloride ratio was increased in the salt leaching. Scaffolds with the total porogen content of 70 wt% exhibited adequate mechanical properties for cartilage tissue engineering applications. The water uptake ratio of nanocomposites was remarkably enhanced by adding 10% cellulose nanofibers. The scaffolds were partially destroyed due to low in vitro degradation rate after more than 20 weeks. Cultivation of isolated rabbit chondrocytes on the fabricated scaffold proved that the incorporation of nanofibers in starch structure improves cell attachment and proliferation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 108, 8 August 2014, Pages 232–238
نویسندگان
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