کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1376104 | 1500658 | 2014 | 13 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Antimicrobial wound dressing nanofiber mats from multicomponent (chitosan/silver-NPs/polyvinyl alcohol) systems Antimicrobial wound dressing nanofiber mats from multicomponent (chitosan/silver-NPs/polyvinyl alcohol) systems](/preview/png/1376104.png)
Novel hybrid nanomaterials have been developed for antimicrobial applications. Here we introduce a green route to produce antibacterial nanofiber mats loaded with silver nanoparticles (Ag-NPs, 25 nm diameter) enveloped in chitosan after reduction with glucose. The nanofiber mats were obtained from colloidal dispersions of chitosan-based Ag-NPs blended with polyvinyl alcohol. Nanofibers (150 nm average diameter and narrow size distribution) were obtained by electrospinning and cross-linked with glutaraldhyde. The effect of crosslinking on the release of silver was studied by atomic absorption spectroscopy. Antimicrobial activity was studied by the viable cell-counting; mats loaded with silver and control samples (chitosan/PVA) with different degrees of cross-linking were compared for their effectiveness in reducing or halting the growth of aerobic bacteria. The results showed superior properties and synergistic antibacterial effects by combining chitosan with Ag-NPs.
► 20 nm Ag-NPs in high concentration (3142 ppm) prepared in chitosan solution.
► High PVA/CS-Ag-NPs blending ratio (60/40, v/v) were established.
► Lower fiber diameter was obtained by increasing chitosan and Ag-NPs content.
► Superior antimicrobial activity of PVA/CS-Ag-NPs nanofibers mats.
Journal: Carbohydrate Polymers - Volume 100, 16 January 2014, Pages 166–178