کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1378908 982014 2005 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis of dehydroalanine fragments as thiostrepton side chain mimetics
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis of dehydroalanine fragments as thiostrepton side chain mimetics
چکیده انگلیسی

Syntheses of dehydroalanine derivatives via a solid-support route, starting from selenocystein, and via conventional solution phase chemistry are described along with initial biological testing. The target compounds were designed as mimetics of the dehydroalanine side chain of the macrocyclic antibiotic thiostrepton that acts on the bacterial ribosome.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 15, Issue 10, 16 May 2005, Pages 2457–2460
نویسندگان
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