کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1383092 | 1500611 | 2016 | 10 صفحه PDF | دانلود رایگان |
• The CHWs were prepared and further surface modified with PLLA to obtain g-CHWs.
• The g-CHWs can disperse more uniformly in PLLA matrix than CHWs.
• The interfacial adhesion between g-CHWs and PLLA matrix was obviously improved.
• Tensile property of g-CHWs/PLLA fiber membrane are superior to PLLA and CHWs/PLLA.
• The g-CHWs/PLLA fiber membrane is more suitable for cell adhesion and growth.
To improve both the mechanical properties and cytocompatibility of poly(l-lactide) (PLLA), rod-like chitin whiskers (CHWs) were prepared, and subsequently surface modified with l-lactide to obtain grafted CHWs (g-CHWs). Then, CHWs and g-CHWs were further introduced into PLLA matrix to fabricate CHWs/PLLA and g-CHWs/PLLA nanofiber membranes by electrospinning technique. Morphologies and properties of the CHWs and g-CHWs were characterized. The surface-grafted PLLA chains played an important role in improving interfacial interaction between the whiskers and PLLA matrix. The g-CHWs dispersed more uniformly in matrix than CHWs, and the as-prepared g-CHWs/PLLA nanofiber membrane showed relative smooth and uniform fiber. As a result, the tensile strength and modulus of the g-CHWs/PLLA nanofiber membrane were obviously superior to those of the pure PLLA and CHWs/PLLA nanofiber membranes. Cells culture results indicated that g-CHWs/PLLA nanofiber membrane is more effectively in promoting MC3T3-E1 cells adhesion, spreading and proliferation than pure PLLA and CHWs/PLLA nanofiber membrane.
Journal: Carbohydrate Polymers - Volume 147, 20 August 2016, Pages 216–225