کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1383807 1500873 2013 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Structure, biosynthesis, and function of bacterial capsular polysaccharides synthesized by ABC transporter-dependent pathways
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Structure, biosynthesis, and function of bacterial capsular polysaccharides synthesized by ABC transporter-dependent pathways
چکیده انگلیسی


• Many pathogenic bacteria produce capsular polysaccharide (CPS) virulence factors.
• The ATP-binding cassette (ABC) transporter-dependent CPS biosynthesis pathway is widespread.
• CPSs biosynthesis is completed in the cytoplasm prior to export to the cell surface.
• CPS export requires a transenvelope multiprotein complex, including the defining ABC transporter.
• Characterized CPS examples contain a conserved glycolipid at the reducing terminus of the glycan.

Bacterial capsules are formed primarily from long-chain polysaccharides with repeat-unit structures. A given bacterial species can produce a range of capsular polysaccharides (CPSs) with different structures and these help distinguish isolates by serotyping, as is the case with Escherichia coli K antigens. Capsules are important virulence factors for many pathogens and this review focuses on CPSs synthesized via ATP-binding cassette (ABC) transporter-dependent processes in Gram-negative bacteria. Bacteria utilizing this pathway are often associated with urinary tract infections, septicemia, and meningitis, and E. coli and Neisseria meningitidis provide well-studied examples. CPSs from ABC transporter-dependent pathways are synthesized at the cytoplasmic face of the inner membrane through the concerted action of glycosyltransferases before being exported across the inner membrane and translocated to the cell surface. A hallmark of these CPSs is a conserved reducing terminal glycolipid composed of phosphatidylglycerol and a poly-3-deoxy-d-manno-oct-2-ulosonic acid (Kdo) linker. Recent discovery of the structure of this conserved lipid terminus provides new insights into the early steps in CPS biosynthesis.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Research - Volume 378, 30 August 2013, Pages 35–44
نویسندگان
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