کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1385240 | 982438 | 2007 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis and antitumor activity of arginine-glucosamine conjugate
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
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چکیده انگلیسی
Using d-glucosamine hydrochloride (GlcNH2·HCl) as starting material, a new amino acid sugar conjugate, arginine-glucosamine (Arg-GlcNH2), was synthesized and characterized by infrared spectroscopy, 13C NMR and element analysis. Its cytotoxicity in vitro was evaluated by MTT assay. The inhibition ratio against human hepatoma cell SMMC-7721 was higher than that of GlcNH2·HCl. This effect was accompanied by a marked increase in the proportion of S cells as analyzed by flow cytometry. In addition, SMMC-7721 cells treated with Arg-GlcNH2 resulted in the induction of apoptosis as assayed qualitatively by agarose gel electrophoresis. The manner of Arg-GlcNH2 cytocidal activity was concluded to be apoptosis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 69, Issue 4, 2 July 2007, Pages 644-650
Journal: Carbohydrate Polymers - Volume 69, Issue 4, 2 July 2007, Pages 644-650
نویسندگان
Li Zhang, Wanshun Liu, Baoqin Han, Dongfeng Wang,