کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1386549 982515 2011 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Hyaluronic acid-g-poly(HEMA) copolymer with potential implications for lung tissue engineering
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Hyaluronic acid-g-poly(HEMA) copolymer with potential implications for lung tissue engineering
چکیده انگلیسی

Tissue engineering represents an attractive potential for regeneration of engineered functional pulmonary tissue. Hyaluronic acid, an extracellular matrix component promotes the growth and proliferation of most cells. The high water affinity of hyaluronic acid (HA) adversely affects its application in the field of tissue engineering. A copolymer of hyaluronic acid and poly(2-hydroxyethylmethacrylate), [poly(HEMA)] appeared as a good choice for the synthesis of a natural-synthetic polymer hybrid matrix with the synergistic properties of both the polymers like water stability and biocompatibility. The copolymer films were stable in water at both acidic and neutral pH in contrast to that of virgin HA films. Grafting significantly alters the mechanical properties of hyaluronic acid. The HA-g-poly(HEMA) is found to be non-cytotoxic to mammalian cells. Further, the polymer was analysed for supporting alveolar cell adhesion and growth and were found suitable for supporting multiple cell types with specific culture requirements. Thus, grafting with poly(HEMA) is a suitable method for the fabrication of stable, cytocompatible natural-synthetic polymer hybrid matrices for varied biomedical applications such as tissue engineering, wound dressings, drug delivery and so forth.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 85, Issue 2, 6 May 2011, Pages 439–445
نویسندگان
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