کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1388122 1500887 2012 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Amylose folding under the influence of lipids
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Amylose folding under the influence of lipids
چکیده انگلیسی

The molecular dynamics simulation technique was used to study the folding and complexation process of a short amylose fragment in the presence of lipids. In aqueous solution, the amylose chain remains as an extended left-handed helix. After the addition of lipids in the system, however, we observe spontaneous folding of the amylose chain into a helical structure, with helical pitch and hydrogen bond network compatible with the V-amylose structure observed in X-ray experiments. Our results suggest that under the influence of external non polar ligands, the conformation of amylose undergoes a transition from an extended to a V-amylose structure in line with experimental evidence.

Figure optionsDownload as PowerPoint slideHighlights
► Amylose dynamics is affected by solvent polarity.
► Fast folding into V-amylose is observed in non polar solvents.
► V-Amylose folding is also observed by interacting with lipids.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Research - Volume 364, 15 December 2012, Pages 1–7
نویسندگان
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