کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1388142 | 982768 | 2010 | 14 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Synthesis and cytotoxic activity of the N-acetylglucosamine-bearing triterpenoid saponins Synthesis and cytotoxic activity of the N-acetylglucosamine-bearing triterpenoid saponins](/preview/png/1388142.png)
Fourteen ursolic acid and oleanolic acid saponins with N-acetyl-β-d-glucosamine, and (1→4)-linked and (1→6)-linked N-acetyl-β-d-glucosamine oligosaccharide residues were synthesized in a convergent manner. The structures of all compounds were confirmed by 1H NMR and 13C NMR spectroscopy and by mass spectrometry, and their cytotoxic activities were assayed in three cancer cell lines. Only oleanolic acid-3-yl β-d-GluNAc showed significant cytotoxicity against HL-60 and BGC-823.
Fourteen ursolic acid and oleanolic acid saponins, where R = GlcNAc or (1→4)-linked and (1→6)-linked GlcNAc oligosaccharide residues were synthesized in a convergent manner and evaluated for their cytotoxic activity in three cancer cell lines. R1 and R2 = H or CH3.Figure optionsDownload as PowerPoint slide
Journal: Carbohydrate Research - Volume 345, Issue 5, 30 March 2010, Pages 607–620