کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1388360 982788 2009 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Glycoside modification of oleanolic acid derivatives as a novel class of anti-osteoclast formation agents
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Glycoside modification of oleanolic acid derivatives as a novel class of anti-osteoclast formation agents
چکیده انگلیسی

Oleanolic acid, a natural product, possesses an anti-osteoclast formation activity. Targeting at discovery of novel and potent anti-bone resorption agents, 22 glycosides of oleanolic acid derivatives (including d-galactopyranosides, d-glucopyranosides, d-xylopyranoses, d-arabopyranoses and d-glycuronic acids) were synthesized at phase-transfer-catalyzed conditions (K2CO3, Bu4NBr, CH2Cl2–H2O) and their inhibitory activity on the formation of osteoclast-like multinucleated cells (OCLs) induced by 1α, 25-dihydroxy vitamin D3 was evaluated in a co-culture assay system. The structure–activity relationships of these compounds were also discussed.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Research - Volume 344, Issue 5, 31 March 2009, Pages 599–605
نویسندگان
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