Effect of saccharide length on the immunogenicity of neoglycoconjugates from synthetic fragments of the O-SP of Vibrio cholerae O1, serotype Ogawa

The binding energy (90%) for an Ogawa-specific Fab (antigen binding component of the antibody) to bind Ogawa LPS is contributed by the terminal perosamine of the Ogawa LPS. Thus, Ogawa-specific immunogens with equal moles of the terminal perosamine of Ogawa LPS induce equivalent titers of anti-Ogawa antibody independent of the extra mass of additional perosamines.