One-pot synthesis of O-glycosyl triazoles by O-glycosylation–click reaction

• Synthesis of 2,3-unsaturated-glycosyl triazoles using iodine and copper catalysts.
• The procedure involved glycosylation and subsequent click reaction in one pot.
• Thirty examples of a variety of triazole-glycosides were obtained in high yields.

2,3-Unsaturated-glycosyl triazoles were synthesized in a simple one-pot process under mild condition via tandem O-glycosylation using iodine promoter and a mild CuAAC reaction. Thirty examples of a variety of O-glycosyl triazoles were obtained in good to excellent yields and α-anomeric selectivity.

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