کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1390459 | 983078 | 2011 | 9 صفحه PDF | دانلود رایگان |

A number of 5-alkoxymethyluracil analogues were synthesized to evaluate their cytotoxic activity. 5-Alkoxymethyluracil derivatives 1 were prepared via known nucleophilic substitution of 5-chloromethyluracil 5 and subsequently transformed to their corresponding nucleosides 2. All prepared compounds were submitted to cytotoxic activity testing against drug sensitive and drug resistant leukaemia cells and solid tumour derived cell lines. In addition, the cytotoxic activity of 5-alkoxymethyluracil analogues 1 and 2 was compared with the previously published 5-[alkoxy(4-nitrophenyl)methyl]uracil analogues 3 and 4. Extensive structure–cytotoxic activity relationship studies are reported.
The synthesis and cytotoxic activity of target compounds 1 and 2 were studied and compared with previously prepared derivatives 3 and 4.Figure optionsDownload as PowerPoint slide
Journal: Carbohydrate Research - Volume 346, Issue 14, 18 October 2011, Pages 2136–2144