کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1390785 983142 2007 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis of the ‘primer–adaptor’ trisaccharide moiety of Escherichia coli O8, O9, and O9a lipopolysaccharide
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis of the ‘primer–adaptor’ trisaccharide moiety of Escherichia coli O8, O9, and O9a lipopolysaccharide
چکیده انگلیسی

Described is the synthesis of the trisaccharide α-d-Manp-(1→3)-α-d-Manp-(1→3)-β-d-GlcpNAcO(CH2)8N3, the glycan portion of which corresponds to the ‘adaptor–primer’ moiety linking the O-chain and core oligosaccharide in the lipopolysaccharide of several Escherichia coli and Klebsiella pneumoniae serotypes. This report represents the first synthesis of this trisaccharide motif, and in the route involved, a key step is a [2+1] coupling of a protected Manp-(1→3)-α-d-Manp glycosyl donor with a GlcpNAc acceptor. The azido group was included in the target to facilitate future preparation of neoglycoconjugates.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Research - Volume 342, Issue 18, 28 December 2007, Pages 2818–2825
نویسندگان
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