کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1390830 | 1500905 | 2007 | 12 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: The synthesis of 2-, 3-, 4- and 6-O-α-d-glucopyranosyl-d-galactopyranose, and their evaluation as nutritional supplements for pre-term infants The synthesis of 2-, 3-, 4- and 6-O-α-d-glucopyranosyl-d-galactopyranose, and their evaluation as nutritional supplements for pre-term infants](/preview/png/1390830.png)
Four methods have been screened for the synthesis of some α-d-glucopyranosides, with the recently reported (Mukaiyama) combination of 2,3,4,6-tetra-O-benzyl-α-d-glucopyranosyl iodide and triphenylphosphine oxide being the most successful, especially in the diastereoselectivity exhibited. The α-d-glucopyranosides so obtained have been deprotected to yield 2-, 3-, 4- and 6-O-α-d-glucopyranosyl-d-galactopyranose. Only the last disaccharide showed any hydrolysis by α-glycosidases but this success was not emulated by mucosal extracts from the small intestine of the pig.
Four methods have been screened for the synthesis of various structural isomers of O-α-d-glucopyranosyl-d-galactopyranose. One of these isomers, namely 6-O-α-d-glucopyranosyl-d-galactopyranose, showed some potential as a nutritional supplement for pre-term infants.Figure optionsDownload as PowerPoint slide
Journal: Carbohydrate Research - Volume 342, Issues 12–13, 3 September 2007, Pages 1793–1804