کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1390965 | 983172 | 2006 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Large-scale chemoenzymatic synthesis of blood group and tumor-associated poly-N-acetyllactosamine antigens
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
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چکیده انگلیسی
Poly-N-acetyllactosamines (pLNs) are common terminal sugars of many N- and O-linked glycan structures present in glycoproteins and glycolipids. Utilizing various glycosyltransferases, we developed new and efficient chemoenzymatic methods for the synthesis of pLNs in gram-scale. Specifically, the use of sialyltransferases and fucosyltransferases enabled us to synthesize and purify 24 blood group and tumor-associated pLN derivatives with α-(2→3)- and α-(2→6)-linked sialic acid, as well as with α-(1→2)- and α-(1→3)-linked fucose. All synthesized derivatives were linked to a short 2-azidoethyl spacer for further modification.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Research - Volume 341, Issue 10, 24 July 2006, Pages 1447–1457
Journal: Carbohydrate Research - Volume 341, Issue 10, 24 July 2006, Pages 1447–1457
نویسندگان
Daniela Vasiliu, Nahid Razi, Yingning Zhang, Nathan Jacobsen, Kirk Allin, Xiaofei Liu, Julia Hoffmann, Ognian Bohorov, Ola Blixt,