Recent advances in the structural library of functionalized quinazoline and quinazolinone scaffolds: Synthetic approaches and multifarious applications

• Recent progress in synthesis of quinazolines and quinazolinones is described.
• New derivatives with potential bioactivity profile are highlighted.
• Several pharmaceutical examples with these skeletons as core motifs are described.
• Some future prospects to continue progression of this chemistry are discussed.

Drug development has been a principal driving force in the rapid maturation of the field of medicinal chemistry during the past several decades. During this period, the intriguing and challenging molecular architectures of nitrogen-containing heterocycles with potential bioactive properties have received significant attention from researchers engaged in the areas of natural product synthesis and heterocyclic methodology, and constituted a continuous stimulus for development in bio(organic) chemistry. In this perspective, the current review article is an effort to summarize recent developments in the environmentally benign synthetic methods providing access to quinazoline and quinazolinone scaffolds with promising biological potential. This article also aims to discuss potential future directions on the development of more potent and specific analogues for various biological targets.

This review article aims at providing recent developments in synthetic methodologies to access quinazoline and quinazolinone scaffolds with their diverse array of potential biological applications. Figure optionsDownload as PowerPoint slide