کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1396342 | 984173 | 2009 | 8 صفحه PDF | دانلود رایگان |
A series of amphiphilic copolymers, dextran-graft-methoxypolyethylene glycol/poly(ε-caprolactone) (Dex-g-mPEG/PCL) were synthesized by grafting both PCL and mPEG chains to dextran, and subsequently the micellar self-assembly behavior of resultant copolymers was investigated. PCL was designed by using Fmoc-protected valine other than organometallic catalyst as the initiator to ring-opening polymerize ε-caprolactone (CL) in view of the safety demand as well as the extra application potential resulting from –NH2 group introduced after Fmoc deprotection. All the copolymers were characterized by 1H NMR, FT-IR and GPC measurements. The prepared copolymers are capable of self-assembling into nanosized spherical micelles in aqueous solution with the diameter of around 100–200 nm determined by TEM image and DLS measurement. The critical micellar concentration (CMC) of the graft copolymers is in the range of 10–100 mg/L determined by the fluorescence robe technique using pyrene. The result also indicated that the CMC of self-assembled micelles could be adjusted by controlling the degree of substitution of mPEG and PCL, and these micelles may find great potential as drug carriers in biomedical fields.
Journal: European Polymer Journal - Volume 45, Issue 4, April 2009, Pages 1024–1031