Peptoidosomes as nanoparticles from amphiphilic block alpha-peptoids using solid-phase-synthesis

• Automated solid phase synthesis of amphiphilic block-oligo-peptoids.
• MALDI-TOF shows that peptoids required no further purification.
• Great influence of hydrophilic part on swelling behaviour.
• Peptoidosomes were formed from all 4 peptoids synthesised.

We show the formation of vesicles from amphiphilic block-oligopeptoids, named here peptoidosomes. The peptoids, synthetic analogues to peptides, were synthesised from solid phase synthesis. Their hydrophilic to hydrophobic aspect ratio was designed to favour the formation of vesicles. MALDI-TOF analysis confirmed their formation. Using a range of hydrophilic parts, we analysed their influence on the quality of the actual peptoids generated but also how different hydrophilic part influence vesicle formation. We found peptoids to be quite resistant to swelling but were able to form peptoidosomes for all peptoids investigated.

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