کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1400962 | 1501692 | 2016 | 12 صفحه PDF | دانلود رایگان |
• Synthesized compounds were structurally characterized using IR, 1H NMR, 13C NMR, 2D NMR and MS spectral studies.
• In-vitro antibacterial and antifungal activity was carried out, against pathogenic microbial strains.
• The crystal structure of 1-Furoyl-2,6-diphenyl-3-methylpiperidin-4-one (10) is determined by X-Ray crystallographic method.
• Molecular docking studies for the synthesized compounds were performed with the GTP binding protein as a target.
A new class of various furoyl derivatives of 2,6-disubstituted piperidin-4-ones were synthesized and characterized by FTIR, NMR, mass and single crystal X-ray diffraction methods. The synthesized compounds were subjected to in-vitro antibacterial and antifungal activities against pathogenic microbial strains. The results pointed out that compounds 11, 12 & 14 displayed pronounced activity towards gram positive bacteria, whereas the compounds 9, 13 & 14 showed a superior inhibition activity against gram negative bacteria. The compound 9 showed a moderate activity towards the fungi. In addition, molecular docking experiments were also carried out.
Journal: Journal of Molecular Structure - Volume 1125, 5 December 2016, Pages 481–492