کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1401068 | 1501693 | 2016 | 5 صفحه PDF | دانلود رایگان |
• pH-induced structural changes of surface immobilized PLGA film.
• Principal component analysis of surface responsive polypeptide film.
• 2D Correlation analysis of pH-dependent surface immobilized PLGA film with increase of pH.
The pH-induced structural changes to surface immobilized poly (l-glutamic acid) (PLGA) films were examined by Fourier transform infrared (FTIR) spectroscopy and two-dimensional (2D) correlation analysis. Significant spectral changes were observed in the FTIR spectra of the surface immobilized PLGA film between pH 6 and 7. The 2D correlation spectra constructed from the pH-dependent FTIR spectra of the surface immobilized PLGA films revealed the spectral changes induced by the alternations of the protonation state of the carboxylic acid group in the PLGA side chain. When the pH was increased from 6 to 8, weak spectral changes in the secondary structure of the PLGA main chain were induced by deprotonation of the carboxylic acid side group.
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Journal: Journal of Molecular Structure - Volume 1124, 15 November 2016, Pages 192–196