Synthesis, spectroscopic characterization, antimicrobial activity and crystal structure of [Ag2(C10H10N3O3S)2(C5H5N)3]

• A new silver complex of sulfamethoxazole is synthesized by reflux method.
• Silver (two) forms distorted tetrahedral and square pyramid geometry.
• Characterized by X-ray crystallography, IR, NMR and UV spectra, CHN and TG analysis.
• The molecular structure of [Ag2(C10H10N3O3S)2(C5H5N)3] is investigated.
• Ag-SMX shows high antibacterial activity than free ligand against gram +ve bacteria.

Silver complex of 4-Amino-N-(5-methyl-1,2-oxazol-3-yl)benzenesulfonamide (sulfamethoxazole) (SMX) has been synthesized and characterized by elemental analysis, infrared, UV and NMR spectroscopy. The title compound, [Ag2(C10H10N3O3S)2(C5H5N)3] crystallizes in the orthorhombic space group Pna21 with lattice parameters a = 17.9527(5), b = 8.6529(3), c = 25.1621(7) Å and Z = 4. The structure is solved by direct method and refined to a final R = 0.0567 for 6732 reflections with I ⩾ 2σ(I). The results of IR, 1H NMR and 13C NMR spectral data suggest the binding of silver atom to the sulfonamide ligand which is in agreement with the crystal structure determination. X-ray analysis revealed that in the title compound, one silver atom is surrounded by three N atoms and one Ag atom leading to a distorted tetrahedral geometry and another silver atom is surrounded by four N atoms and one Ag atom leading to a slightly distorted square pyramid geometry with Ag⋯Ag separation distance of 3.026 Å. The dihedral angle between phenyl and isoxazole ring is 85.7(4)°. In the crystal structure, the molecules are linked via NH⋯O, CH⋯O intermolecular and CH⋯O intramolecular interactions. Silver complex of sulfamethoxazole has been studied by electrical and thermal analysis. Silver sulfamethoxazole presents different antibacterial behavior against Escherichia coli and Staphylococcus aureus strains.

ORTEP view of the title compound shows two silver atoms leading to distorted tetrahedral and square pyramid geometry.Figure optionsDownload as PowerPoint slide