کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1402704 1501754 2014 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Stereospecific ligands and their complexes. Part XII. Synthesis, characterization and in vitro antiproliferative activity of platinum(IV) complexes with some O,O′-dialkyl esters of (S,S)-ethylenediamine-N,N′-di-2-propanoic acid against colon cancer (HCT-1
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Stereospecific ligands and their complexes. Part XII. Synthesis, characterization and in vitro antiproliferative activity of platinum(IV) complexes with some O,O′-dialkyl esters of (S,S)-ethylenediamine-N,N′-di-2-propanoic acid against colon cancer (HCT-1
چکیده انگلیسی


• Synthesis of three new platinum(IV) complexes with bidentate N,N′-ligand.
• Complexes were characterized by infrared, 1H and 13C NMR spectroscopy.
• In vitro antiproliferative activity on tumor cell lines: HCT-116 and MDA-MB-231.

Synthesis of three new platinum(IV) complexes C1–C3, with bidentate N,N′-ligand precursors, O,O′-dialkyl esters (alkyl = propyl, butyl and pentyl), of (S,S)-ethylenediamine-N,N′-di-2-propanoic acid, H2-S,S-eddp were reported. The reported platinum(IV) complexes characterized by elemental analysis and their structures were discussed on the bases of their infrared, 1H and 13C NMR spectroscopy. In vitro antiproliferative activity was determined on tumor cell lines: human colon carcinoma HCT-116 and human breast carcinoma MDA-MB-231, using MTT test.

The complexes have been obtained by direct reaction of potassium-hexachloridoplatinate(IV) with corresponding esters of (S,S)-ethylenediamine-N,N′-di-2-propanoic acid.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular Structure - Volume 1062, 24 March 2014, Pages 21–28
نویسندگان
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