کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1402704 | 1501754 | 2014 | 8 صفحه PDF | دانلود رایگان |

• Synthesis of three new platinum(IV) complexes with bidentate N,N′-ligand.
• Complexes were characterized by infrared, 1H and 13C NMR spectroscopy.
• In vitro antiproliferative activity on tumor cell lines: HCT-116 and MDA-MB-231.
Synthesis of three new platinum(IV) complexes C1–C3, with bidentate N,N′-ligand precursors, O,O′-dialkyl esters (alkyl = propyl, butyl and pentyl), of (S,S)-ethylenediamine-N,N′-di-2-propanoic acid, H2-S,S-eddp were reported. The reported platinum(IV) complexes characterized by elemental analysis and their structures were discussed on the bases of their infrared, 1H and 13C NMR spectroscopy. In vitro antiproliferative activity was determined on tumor cell lines: human colon carcinoma HCT-116 and human breast carcinoma MDA-MB-231, using MTT test.
The complexes have been obtained by direct reaction of potassium-hexachloridoplatinate(IV) with corresponding esters of (S,S)-ethylenediamine-N,N′-di-2-propanoic acid.Figure optionsDownload as PowerPoint slide
Journal: Journal of Molecular Structure - Volume 1062, 24 March 2014, Pages 21–28