کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1403562 | 984833 | 2007 | 7 صفحه PDF | دانلود رایگان |
We describe the effect of surface-modified hydroxyapatite (HAp) nano-crystals on biocompatibility of a new-type nanocomposite consisting of poly(ε-caprolactone) (PCL) and HAp. Surface-modified hydroxyapatite (HAp) nano-crystals were prepared by chemically grafting PCL on HAp surfaces. Time-dependent phase monitoring indicated that PCL surface-grafting contributed to the enhanced dispersion of HAp at nano-level in the PCL solution. The protein adhesion and cell experiments showed that the presence of PCL-grafted HAp nano-crystals in nanocomposites contributed to the enhanced biocompatibility. PCL-grafted HAp in nanocomposites provided more favorable environments for protein adsorption, compared with unmodified HAp. Nanocomposites containing PCL-grafted nanophase HAp showed positive effects on adhesion and proliferation of NIH3T3 fibroblasts.
Journal: European Polymer Journal - Volume 43, Issue 5, May 2007, Pages 1602–1608