Assignment of NMR data and relative stereochemistry determination of paraconic acid derivatives

• The four paraconic acid derivatives had their structures fully elucidated.
• A complete 1H and 13C NMR structural assignment was realized.
• NOEDIFF experiments were used to determine the relative stereochemistry.

γ-Butyrolactones 4a1, 4a2, 4b1 and 4b2 were carefully studied through NMR experiments. 1H NMR, 13C {1H} NMR, COSY, HMQC, HMBC and J-res experiments were performed to provide the needed structure information. NOE between protons distributed around the stereocenters were thus used to determine the relative configuration of the molecules.

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