کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1405306 1501761 2013 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Unambiguous determination of conformation and relative configuration of a multiple stereo-centre molecule Rifamycin-S by using scaled residual dipolar couplings: A case study
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Unambiguous determination of conformation and relative configuration of a multiple stereo-centre molecule Rifamycin-S by using scaled residual dipolar couplings: A case study
چکیده انگلیسی


• Importance of scaled- RDCs in NMR spectroscopy of organic molecules is discussed.
• The approach is exemplified with a multiple stereo-centre molecule, Rifamycin-S.
• The method allows to identify the exact conformation and relative configuration.
• Merits of the method and some limitations about its sensitivity are also discussed.

Residual dipolar couplings (RDC) as additional orientational constraints offer a powerful means of determining molecular structures compared to the conventional (3JHH + NOE) based analysis. The recent advent of cross-linked polymer gel alignment media that are compatible for organic solvents has added further impetus to the RDC-enhanced NMR spectroscopy of small molecules, for precise structural elucidations. However, optimum strength of alignment for molecules dissolved in suitable anisotropic media is crucial for unambiguous measurement of RDCs. In contrast to the mechanical and chemical methods that are in practice, herein we exploit strain-induced fixation of alignment of PDMS/CDCl3 gels and conceptually known variable-angle assisted scaling strategies for tuning optimum range of alignment, thereby to record unambiguous one-bond C–H RDCs as well as the corresponding JCH scalar couplings in a model multiple-stereo centre molecule, Rifamycin-S. The analysis aided by the refined RDCs thus obtained, could single-out the exact conformation as well as relative configuration of Rifamycin-S, from its 256 configurational possibilities.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular Structure - Volume 1053, 5 December 2013, Pages 122–126
نویسندگان
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