Synthesis, characterization, antibacterial, antifungal and immunomodulating activities of gatifloxacin–metal complexes

Gatifloxacin is a potent fluoroquinolone antibacterial agent. It is reported and our previous work has also proved that availability of gatifloxacin is reduced by co-administration of metallic supplements. For better understanding of these interactions, complexes of gatifloxacin were synthesized with Mg(II), Ca(II), Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) (usually present in human body) and their structures were established with the help of spectroscopic studies like IR, UV, and NMR. The IR spectra of the complexes suggest that the gatifloxacin behaves as a monoanionic bidentate ligand. In vitro antibacterial, antifungal, anti-inflammatory and immunosuppressive activities of the gatifloxacin and the complexes were tested. GTX-Ni and GTX-Cu has excellent anti-inflammatory activity.