کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1406590 1501832 2010 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Multivariate control charts based on net analyte signal and near infrared spectroscopy for quality monitoring of Nimesulide in pharmaceutical formulations
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Multivariate control charts based on net analyte signal and near infrared spectroscopy for quality monitoring of Nimesulide in pharmaceutical formulations
چکیده انگلیسی

Multivariate control charts based on the net analytical signal, in conjunction with near infrared spectroscopy, were developed to monitor the quality of a pharmaceutical formulation containing Nimesulide. Three control charts were developed: the NAS chart that corresponds to the analyte of interest (Nimesulide in this case), the interference chart that corresponds to the contribution of other compounds in the sample and the residual chart that corresponds to nonsystematic variation. From the limits estimated for each chart using samples inside the quality specifications, it was possible to identify the samples that were outside the specifications concerning Nimesulide concentration and to identify the presence of different constituents in the standard formulation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular Structure - Volume 982, Issues 1–3, 8 October 2010, Pages 73–78
نویسندگان
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