کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1407288 1501898 2007 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Aggregation processes of biomolecules in presence of trehalose
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Aggregation processes of biomolecules in presence of trehalose
چکیده انگلیسی

Among disaccharides, trehalose, a naturally-occurring glass-forming disaccharide, is particularly effective in terms of its ability to preserve several organisms under stress conditions. The present work is aimed to investigate the bioprotective action of trehalose on lysozyme as a function of temperature. In order to extract quantitative information about the dimensional changes of the proteins, we performed Small Angle Neutron Scattering measurements on lysozyme/D2O solutions in absence and in presence of the disaccharide. The findings emphasise the capability of trehalose to stabilise the protein, activating aggregation processes.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular Structure - Volume 840, Issues 1–3, 17 September 2007, Pages 114–118
نویسندگان
, , , , ,