کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1407771 | 1501701 | 2016 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
N4-methylation changes the conformation of (3S,6S)-3-alkyl-6-benzylpiperazine-2,5-diones from folded to extended
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
• A series of novel N-methylated and N,N′-dimethylated 2,5-DKPs were prepared.
• Conformational analysis of N-methylated and N,N′-dimethylated 2,5-DKPs based on 1H NMR spectroscopy were performed.
• Single crystal X-ray structural analysis of N1-methylated and N4-methylated 2,5-DKPs was performed.
• N4-methylation of mono-benzylated 2,5-DKPs was found to change their conformation from folded to extended.
N4-methylation of (3S,6S)-3-alkyl-6-benzylpiperazine-2,5-diones (S,S)-1a–c was found to change their folded conformation to an extended conformation. Conformational aspects of N1- and/or N4-methylated (S,S)-1a–c were revealed by single crystal X-ray crystallography and 1H NMR spectroscopy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular Structure - Volume 1116, 15 July 2016, Pages 37–44
Journal: Journal of Molecular Structure - Volume 1116, 15 July 2016, Pages 37–44
نویسندگان
Michiyasu Nakao, Yuta Hiroyama, Shintaro Fukayama, Shigeki Sano,