کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1408011 | 1501717 | 2015 | 7 صفحه PDF | دانلود رایگان |
• Template synthesis of macrocyclic complexes.
• Square pyramidal geometry proposed for Cr & Fe complexes.
• Molecular modelling & docking studies carried out.
• Screening for antimicrobial and antioxidant activity was done.
The macrocyclic complexes of pharmaceutical importance with trivalent transition metals have been synthesized by [1 + 1] condensation of succinyldihydrazide and thiophenedicarboxaldehyde, via template method, resulting in the formation of the complex [MLX] X2; where L is (C10H10N4O2S), a macrocyclic ligand, M = Cr (III) and Fe (III) and X = Cl−, CH3COO− or NO3−NO3−. These complexes have been characterized with the help of elemental analyses, molar conductance measurements, magnetic susceptibility measurements, ultraviolet, infrared, far infrared, electron spin resonance, mass spectral studies and powder x-ray diffraction analysis. On the basis of all these studies, mononuclear complexes having 1:2 electrolytic nature with a five coordinated square pyramidal geometry have been proposed. Powder diffraction XRD indicates the presence of triclinic crystal system with p bravais lattice for the representative complex. All the metal complexes have also been explored for their in vitro antimicrobial and antioxidant activities.
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Journal: Journal of Molecular Structure - Volume 1100, 15 November 2015, Pages 208–214