کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1408030 1501717 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis, structure investigation and biological evaluation of 2-thiophene N(4)-phenylthiosemicarbazone and its three metal derivatives
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis, structure investigation and biological evaluation of 2-thiophene N(4)-phenylthiosemicarbazone and its three metal derivatives
چکیده انگلیسی


• Heterocyclic thiosemicarbazone.
• Cytotoxic studies.
• Hirshfeld surface.
• Fingerprint plots.

A 2-thiophene N(4)-phenylthiosemicarbazone (HL) ligand and its three metal derivatives [CuL2 ] (1), [NiL2] (2) and [PdL2] (3) are synthesized and characterized by elemental analysis, IR spectra, mass spectra as well as the single-crystal X-ray diffraction. Compounds 1–3 have the identical architectures in which the Schiff bases L− ions act as the bibasic chelating ligands with thiolate S and imine N atoms as the donor sites. Cytotoxic studies carried out in vitro against human liver hepatocellular carcinoma HepG2 cells and human normal hepatocyte QSG7701 cells show that 1 can be able to inhibit cell proliferation growth. Compound 1 promotes a dose-dependent apoptosis in HepG2 cells. The potential structure-activity relationships among HL and 1–3 are further investigated by Hirshfeld surface combining fingerprint plots.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular Structure - Volume 1100, 15 November 2015, Pages 376–383
نویسندگان
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